Influence of donor-recipient strain combinations on immunologic responses after allogeneic rat small bowel transplantation.
نویسندگان
چکیده
Orthotopic SBTx with ponocaval drainage l was perfonned with or without immunosuppression in 12 fully allogeneic rat strain combinations between LEW (RTI). BN (RT"). pva (RTle ). and ACI (RTla) rats (purchased from Harlan Sprague-Dawley Inc. Indianapolis. IN). For immunosuppression. FK 506 dissolved in HCO-60 and D-mannitol carrier solvent (gift from Fujisawa Pharm Co Ltd. Osaka. Japan) was given intramuscularly (0.64 mglkgld on days 0 to 13).
منابع مشابه
Graft-versus-host disease in fully allogeneic small bowel transplantation: incidence of the disease and strain combinations.
WE PREVIOUSLY reported that fully allogeneic small bowel transplantation (SB11 from Lewis (LEW) to Brown Norway (BN) rats caused fatal graftversus-host disease (GVHD) when the recipients were treated with a short course of FK 506. 1 Graft-versus-host disease has also been well described after parent to F 1 hybrid SBT,2 in which immune reaction between donor and recipient is completely unbalance...
متن کاملThe influence of donor and recipient strains in isolated small bowel transplantation in rats.
W E recently reported that intestinal transplantation from Lewis (LEW) to Brown Norway (BN) was intractable to FK 506 therapy because of a high incidence of a graft-versus-host disease (GVHD) syndrome) similar to that in the parent to F) hybrid offspring experiments of Monchik and Russell.2 However, transplantation in the opposite direction (BN to LEW) was highly successful without either GVHD ...
متن کاملThe transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor.
The successful reconstitution of adaptive immunity to human cytomegalovirus (CMV) in hematopoietic stem cell transplantation (HSCT) recipients is central to the reduction of viral reactivation-related morbidity and mortality. Here, we characterized the magnitude, specificity, phenotype, function, and clonotypic composition of CMV-specific T-cell responses in 18 donor-recipient pairs both before...
متن کاملFulminant Crohn's colitis after allogeneic stem cell transplantation.
We report a case of fulminant Crohn's colitis that occurred following non-myeloablative allogeneic stem cell transplantation for Hodgkin's lymphoma. Adoptive transfer of inflammatory bowel disease by haematopoietic cells is recognised in several animal models of inflammatory bowel disease and remission of Crohn's disease has been reported in patients who have received a bone marrow transplant. ...
متن کاملDevelopment of heterotopic transplantation of the testis with the epididymis to evaluate an aspect of testicular immunology in rats
Transplantation of testicular cells and tissues has been studied for the investigation of immunology of the testis, which is an immunologically privileged organ. However, reports of transplant of the testis at organ level have been extremely limited because of technical difficulties of the orthotopic testis transplantation (OTT) in experimental animals. In the present study, we developed a new ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Transplantation proceedings
دوره 26 3 شماره
صفحات -
تاریخ انتشار 1994